Full Symposium Descriptions

 

Analytical Sciences Symposia

A01 - Diffraction Imaging Across Disciplines

ORGANIZERS:
Andrew Minor, Professor of Materials Science and Engineering, Facility Director of the National Center for Electron Microscopy, Molecular Foundry, Lawrence Berkeley National Laboratory
Jose Rodriguez, Department of Chemistry & Biochemistry, University of California, Los Angeles

Recent advancements in STEM and electron nanobeam technologies allow micron scale mapping of repeat structures to image complex samples with nanometer resolution. These advances take advantage of fast electron detectors to collect diffraction patterns that facilitate the accurate structural analysis of atomic order across materials, including low-Z materials that often present substantial challenges. The scope of problems interrogated by these approaches is broad, ranging from naturally occurring biomaterials to functional and complex microstructures. This symposium will bring together the computational, materials, chemical and biological microscopy communities to discuss recent developments in the broad fields of electron diffraction, diffractive nanoimaging, and cryoEM to facilitate the study of varied materials, both hard materials studied with high resolution 4D-STEM and materials not typically suited for high resolution structural analysis.

A02 - Advances in Focused Ion Beam Instrumentation, Applications and Techniques in and Materials and Life Sciences

ORGANIZERS:
Suzy Vitale, Carnegie Institution for Science
Annalena Wolff, Queensland University of Technology
Joshua Sugar, Sandia National Laboratories

The objective of this symposium is to provide an overview of recent developments of focused ion beam instrumentation, as well as a platform for FIB users to share and discuss novel applications and techniques across multiple scientific disciplines. Our focus will be on innovative approaches to imaging, sample preparation, fabrication, and analytics that go beyond conventional methods in materials and life sciences, and the research that drives these new applications.

A03 - Microscopy and Microanalysis for Real World Problem Solving

ORGANIZERS:
Ke-Bin Low, BASF Corporation
Xiaofeng Zhang, Nanosys Inc.
Jeremy Beebe, Dow
Abigail Lindstrom, NIST

Microscopy and microanalysis of real world samples present special challenges. Non-ideal samples may not lend themselves to established methodologies for preparation and analysis. Sample amounts and background information about the material and the problem may be limited, and the time frame for producing results may be very short. This symposium will focus on ways in which biologists, physical and materials scientists develop unique and creative solutions for sample preparation, data acquisition and analysis, providing meaningful results to solve problems in the real world.

A04 - New Frontiers in In-Situ Electron Microscopy in Liquids and Gases (L&G EM FIG Sponsored)

ORGANIZERS:
Huolin Xin, University of California, Irvine
Wei-Chang D. Yang, NIST
Stephen House, University of Pittsburgh

New developments in electron microscopy (EM) instrumentation now enable the observation and measurement of nanoscale processes in liquid and gas environments for in situ/operando studies. These studies, performed at high spatial resolution and under various stimuli such as heat, electric fields, and reactive liquid/gas environments, can provide fundamental insight into the structure, chemistry, and functionality of materials and biological molecules in their native or working conditions. This in-week symposium sponsored by the MSA Electron Microscopy in Liquids and Gases (EMLG) Focused Interest Group will provide a platform for communicating technical challenges and practical knowledge associated with capturing dynamic processes in liquids or gases with EM. We will also draw attention to new approaches and emerging technologies in data acquisition and analysis, focusing on the horizon of the field and discussing future roadmaps that may lead there.

A05 - Advances in Analytical STEM-in-SEM

ORGANIZERS:
Jason Holm, National Institute of Standards and Technology
Dagmar Gerthsen, Karlsruhe Institute of Technology
Hendrix Demers, Hydro-Québec, Center of Excellence in Transportation Electrification and Energy Storage

STEM-in-SEM is attracting significant interest from diverse groups, due to advances in hardware (e.g., pixelated programmable electron detectors, aberration correction, energy loss spectrometers) and methodology (e.g., 4-D STEM, ?-scan dark-field orientation mapping, ptychography, phase contrast imaging, etc.) that are both adaptable to and/or designed specifically for SEM. This symposium will provide an opportunity to discuss advances in instrumentation, simulation methods, analytical techniques, and imaging and diffraction applications that enable materials characterization with transmitted electrons in an SEM. Emphasis will be on new techniques and those that push the boundaries of low voltage scanning transmission microscopy. Target attendees include scientists, engineers, and lab technicians working in materials science, metallurgy, nanotechnology, geology, and biology.

A06 - Full System and Workflow Automation for Enabling Big Data and Machine Learning in Electron Microscopy

ORGANIZERS:
Andrew Barnum Barnum, Thermo Fisher Scientific
Joerg Jinschek, Ohio State University
Wouter Van den Broek, Humboldt University of Berlin

Cutting-edge research in life science and materials science, in industry and academia requires not only state-of-the-art instrumentation, but also innovative approaches to integrating digital science with system, workflow and data analysis automation. Over the past several years, a critical mass of new computing and microscope technologies has formed, poised to enable revolutionary changes in data collection and analysis using both fully automated microscopes and feedback loops as well as machine learning approaches. This symposium will feature recent progress towards creating complete automation workflows ranging from sample preparation through to data correlation and reporting, including system integration with experiment automation and data analysis, methodology for abstracting user-microscope interaction, and the use of novel methods to provide on-line feedback of system parameters.

A07 - Vendor Symposium

ORGANIZERS:
Jay Potts, University of South Carolina
Lena Kourkoutis, Cornell University

This symposium is a forum for vendors to highlight important breakthroughs in technology and methodology developed by companies working at the cutting edge of microscopy, microanalysis, and image processing. It covers new instrumentation, technologies and methods that advance all fields of microscopy and microanalysis for both physical and biological sciences. It will provide an open forum for the exchange of ideas and best practices.

A08 - Data Management, Version Control, and Multiformat Analysis in Electron Microscopy

ORGANIZERS: Josh Sugar, Sandia National Laboratories
Suzy Vitale, Carnegie Institution for Science
Joe McKeown, Lawrence Livermore National Laboratory

Microscopy labs have the difficult task of storing and managing image, spectrum, and diffraction data in multiple dimensions, which fills several terabytes of drive space after only months of operation. The ability for multiple users to (re)analyze that data, while keeping track of the original raw data and using multiple proprietary file formats, is a challenging problem that needs innovative solutions. The goal of this symposium is to provide a forum where new ideas can be presented on how to solve these data management issues, including storage, transfer, version control, analysis, and proprietary formats that are incompatible on multiple platforms.

A09 - Moon dust, Minerals and Microscopy

ORGANIZERS:
Kate Burgess, U.S. Naval Research Laboratory
Michelle Thompson, Purdue University
Jessica Barnes, University of Arizona

The analysis of earth and planetary materials through microscopy and other microanalytical techniques is fundamental to improving our understanding of the formation and evolution of Earth and other planets across the solar system. These techniques are especially important in the wake of renewed interest in returning to the Moon, and past, present, and future sample return missions to other planetary bodies. The proposed session solicits papers focused on state-of-the-art sample analysis and preparation techniques for terrestrial and extraterrestrial materials.

A10 - Unresolved Challenges in Quantitative X-ray Microanalysis

ORGANIZERS:
Aaron Torpy, CSIRO Mineral Resources, Clayton, Australia
Nick Wilson, CSIRO Mineral Resources, Clayton, Australia
Hendrix Demers, Hydro-Québec's Center of Excellence in Transportation Electrification and Energy Storage, Varennes, Canada
Aurélien Moy, Department of Geoscience, University of Wisconsin-Madison, Madison, WI, USA

X-ray spectrometry was developed over a century ago (Bragg, 1914), and its use in quantitative microanalysis is entering its 7th decade (Castaing, 1951). In the intervening years, x-ray microanalysis has developed into an enormously powerful analytical technique, with the ability to detect the elements from Li to Pu, quantify their abundance with ppm precision, and do so with spatial resolution ranging from the micro- to atomic scales. This symposium will discuss the current challenges in x-ray microanalysis, and explore approaches to further improve the resolution, sensitivity, reliability, applicability, and practicality of the technique.

A11 - Portable- and Laboratory-based Approaches to Analysis in Cultural Heritage

ORGANIZERS:
Thomas Lam, Smithsonian Institution, Museum Conservation Institute, Suitland, MD
Barbara Berrie, National Gallery of Art, Washington, DC

Scientific analysis of heritage objects is critical to learning about the technologies used for their manufacture and providing information about their meaning to previous cultures. It involves analysis of the macro/microstructure and the distribution of chemical phases within objects. This knowledge informs their conservation and public exhibition, and increases our understanding of other cultures. A range of portable and laboratory approaches for non-destructive or minimally invasive techniques is available. This symposium explores the applications and results obtained using different analytical instruments through invited and contributed presentations from students, conservators, conservation scientists, and other interested researchers in the field.

A12 - Microscopy and Microanalysis of Biomineralized and Biomimetic Materials and Structures

ORGANIZERS:
Kenneth Livi, Johns Hopkins University
Sue Okerstrom, Lichen Labs LLC

Nature builds functional systems with a handful of materials that have emergent properties at different scales. Calcite crystals form both the self-sharpening teeth sea urchins grind into rock and armor protection on exoskeletons of some ants. Organic molecules are assembled to produce structural color in butterfly wings and peacock feathers, super-hydrophobic lotus leaves, low friction sharkskin, and super-adhesive gecko's feet. In addition, minerals grown with biological influence are important archives of Earth history and offer new frontiers for materials biomimicry research. Microscopy and microanalysis are important in characterizing material structure and chemistry to elucidate biomineralization mechanisms and the processes responsible for properties emergent on the macroscopic scale. This symposium aims to bring together analysts from broad perspectives to share successes and difficulties of measurement of both hard and soft materials from natural, biomimetic, or engineered materials utilizing a variety of radiation sources and detection systems.

 

Biological Sciences Symposia

B01 - 3D Structures: From Macromolecular Assemblies to Whole Cells (3DEM FIG)

ORGANIZERS:
Melanie Ohi, University of Michigan Life Sciences Institute
Teresa Ruiz, University of Vermont
Cheri Hampton, UES, Inc., AFRL/RXAS Wright-Patterson Air Force Base
William Rice, NYU Langone Health

Our understanding of the 3D structure and functional subtleties of complex biological systems has skyrocketed due to recent advances in EM imaging technology and hybrid methodologies. This symposium will highlight structural studies of macromolecules, microorganisms, cells, and tissues using state-of-the-art high-resolution techniques. These techniques include single particle cryo-EM, cryo-electron tomography, helical reconstruction, STEM; AFM, X-ray crystallography, and molecular modeling. Biological topics of interest include: cellular architecture, metabolism, trafficking, communication, and division; gene regulation, transcription, and translation; host-pathogen interactions and virus structure; In situ studies using TEM and SEM, and all aspects of structure-function studies of biological assemblies.

B02 - Visualizing Cells with Cryo-ET

ORGANIZERS:
Grant Jensen, Caltech
Yi-Wei Chang, University of Pennsylvania
Danielle Grotjahn, Scripps Research Institute
Matt Swulius, Penn State College of Medicine

In the last several years cryo-electron tomography (cryo-ET) has made it possible to visualize large macromolecular assemblies inside intact cells in a near-native, "frozen-hydrated" state in 3-D to a few nanometers resolution. Increasingly, atomic models of individual proteins and smaller complexes obtained by X-ray crystallography, NMR spectroscopy, or other methods can be fit into cryotomograms to reveal how the various pieces work together inside cells. A few good cryotomograms is therefore sometimes all that is really needed to distinguish between competing models. The range of cellular samples that cryo-ET can inspect is dramatically expanding to both larger and smaller objects, and its power is being amplified by correlated light and electron microscopy (CLEM) targeting. Further technical advances are making cryo-ET faster and higher resolution. Symposium speakers will show examples of current results and technical developments expanding the power and applicability of the method.

B03 - From Images to Insights: Working with Large Multi-modal Data in Cell Biological Imaging

ORGANIZERS:
Kedar Narayan, NIH/NCI & FNL
Cam Robinson, St. Jude Children's Research Hospital
Jonathan Lefman, nvidia

"So, you've collected these massive multi-modal image data sets. Now what?" Biological imaging is producing ever larger data sets but is also quickly becoming multi-modal, with disparate imaging technologies being often utilized. Yet the ability to handle and analyze these data often lags far behind, especially in smaller labs and core facilities. Appropriate integration and correlation of disparate data streams at various scales, and portability of automated solutions remain daunting. This symposium aims to address issues and solutions stemming from large and multi-modal image data in cell biology, including image processing, correlation, segmentation/visualization and analysis, especially in the context of open-source options.

B04 - Michael Rossmann Memorial Symposium

ORGANIZERS:
S. Saif Hasan, Department of Biochemistry and Molecular Biology, University of Maryland school of Medicine, Baltimore MD
Terje Dokland, Department of Microbiology, University of Alabama at Birmingham, Birmingham AL

Michael G. Rossmann was a pioneer in the field of structural biology. His contributions to X-ray crystallography and application of hybrid methods to electron microscopy revolutionized biomolecular structure determination. Michael pushed the boundaries of structural biology by developing methodologies such as the molecular replacement method and determining some of the first structures of entire viruses. Michael published nearly 600 papers during a career that spanned over half a century. This symposium will provide remembrances of Michael's achievements in structural biology and feature prominent speakers in the fields of X-ray crystallography and cryo-electron microscopy, two fields on which Michael left an indelible mark.

B05 - Imaging, Microscopy, and Micro/Nano-Analysis of Pharmaceutical, Biopharmaceutical, and Medical Health Products – Research, Development, Analysis, Regulation, and Commercialization (FIG associated)

ORGANIZERS:
Daniel Skomski, Merck & Co. Inc.
Annie Muske-Dukes, Thermo Fisher Scientific

This symposium, sponsored by the Pharmaceuticals Focused Interest Group (FIG), will present diverse content related to the research, development, manufacture, and use of pharmaceuticals, medical products, and devices. The intent is to connect subject matter experts dealing with the application of microscopy, imaging, and micro/nano-analysis towards problems of interest to the pharmaceutical, biopharmaceutical, medical, device, and health fields. In-depth technical presentations will address the unique problems that arise during drug discovery and development, method development and optimization, vaccine research, formulation, biocompatibility, production, product life cycle management, and eventual patient use. Addressed topics in the research include material design and properties, physiochemical characterization (actives, excipients, contaminants, small molecule/large molecule/intermediate, polymorphs, particles), product performance, pharmacology, manufacturing, failure modes, biocompatibility, stability, shelf-life, sterility, etc. Also of interest is an understanding of regulations and data integrity concerns as applied to the pharmaceutical industry. Vendors and service providers are encouraged to submit abstracts which describe the use of their technologies as they apply to pharmaceutical industry problems.

B06 - Multi-Modal Multi-Dimensional Microscopy

ORGANIZERS:
James Fitzpatrick, Washington University School of Medicine
Xiao-Ying Yu, Pacific Northwest National Laboratory
Si Chen, Argonne National Laboratory
Ben Giepmans, University Medical Center Groningen, Groningen, NL

Microscopy has evolved from a disparate set of imaging approaches to a cohesive array of tools used to investigate both the structure and dynamic function of complex systems. However, to comprehensively elucidate both spatial and dynamic aspects, it has become necessary to combine multiple imaging modalities. Innovations in correlative microscopy have led to advancements in both soft materials and biomedical research. This symposium aims to highlight technical innovations in sample preparation, handling and transfer of cryo specimens in correlative imaging workflows and instrument hardware development along with novel applications of CLEM, volume EM, analytical spectroscopy / SIMS and X-Ray imaging & analysis, including big-data management and artificial intelligence-based analysis pipelines.

B07 - Challenges and Advances in Electron Microscopy Research and Diagnosis of Diseases in Humans, Plants and Animals (FIG associated)

ORGANIZERS:
Claudia Lopez, Oregon Health & Science University
Marcela Redigolo, West Virginia University
Ru-Ching Hsia, University of Maryland
Han Chen, Penn State

This symposium covers diverse content related to the research and diagnosis of diseases in human, animal and plants. The application of microscopy techniques to study genetic, metabolic or infectious diseases faces many challenges including specimen preservation, preparation, data collection and analysis. Often these workflows are specific to the tissue type or model. Importance is placed on techniques and protocols developed to use on both research and clinical laboratories. Presentations generally address the unique challenges related to the use of advanced microscopy to the detection and diagnosis of a disease. Target attendees include scientists from all levels of bio-imaging expertise and related backgrounds.

B08 - Cryo-EM in Drug Discovery

ORGANIZERS:
Leah Frye, Schrodinger
Giovanna Scapin, NanoImaging Services
Christel Verboven, Thermo Fisher Scientific

Recent advances in cryo-EM technology have resulted in the ability to obtain structures of pharmaceutically relevant proteins with atomic level resolutions in a timely fashion. Importantly, cryo-EM greatly expands the availability of structures for large protein assemblies and membrane bound proteins which have been difficult to access via X-ray crystallography. This symposium will focus on the use of cryo-EM in drug discovery. Presentations will describe projects utilizing cryo-EM structures to drive structure-based drug discovery efforts for the optimization of potency and selectivity, including selectivity against ADMET targets, in projects from both industrial and academic groups.

B09 - To fix or not to fix? A question for biological samples

ORGANIZERS:
Alice Dohnalkova, Pacific Northwest National Laboratory
Gail Celio, University of Minnesota

Whether we use a robust, time-honored chemical fixation or advanced cryo-preparation methods, it's important to define the desired information before we embark on specimen preparation for light and/or electron microscopy. It could be an urgent, high-throughput imaging stream, or the quest for obtaining the absolute value and ultrastructure. We need to make decisions that will produce the best results for the project outcome. So regardless if you reach for a microwave or a Dewar, we invite you to discuss the pros and cons with us, and share your optimized sample preparations and meaningful results that worked for you.

B10 - Cryo-EM at local, regional, and national cryo-EM centers

ORGANIZERS:
Claudia Lopez, Oregon Health & Science University and Pacific North West CryoEM Center (PNCC)
Elizabeth Wright, University of Wisconsin-Madison
Clint Potter, New York Structural Biology Center and National Center for CryoEM Access and Training (NCCAT)

This symposium covers diverse content related to the access of cryoEM technology by novice and advanced practitioners. Over the past decades, scientific manuscripts presenting cryoEM data have been growing at a fast pace. With the installation of cutting-edge microscopes all over the globe, this technology is booming. Nevertheless, scientific researchers are struggling to access such instrumentation due to elevated costs and/or lack of adequate training. In the United States, use of this technology has increased largely to the creation of NIH-funded cryoEM/ET centers which include instrument access, hands-on training and learning materials. Across the globe, similar national and international centers have been established to meet the demand for access to cryoEM/ET instrumentation and expertise. In this symposium, importance is placed on user experience and scientific advances obtained at these cryoEM/ET centers. Presentations will also address the unique challenges related to the use of advanced microscopy. Target attendees include scientists from all levels of expertise and related backgrounds.

B11 - Frontiers in Fluorescence Lifetime and Super-resolution Imaging of Biological Structures and Dynamics

ORGANIZERS:
Michelle Digman, University of California Irvine
Matthew Lew, Washington University in St. Louis
Kevin Welsher, Duke University
Andreas Gahlmann, University of Virginia

Fluorescence lifetime imaging microscopy (FLIM) and super-resolution microscopy (SRM) have become powerful tools in bioimaging to map protein interactions or identify environmental conditions of fluorescent probes through fluorophores' excited state lifetimes or emission properties. Recently there have been remarkable developments in bioimage FLIM data analysis, use of patterned excitation light, and feedback for SRM with single nanometer resolution, as well as imaging the emission spectra and/or orientation of fluorophores for probing hydrophobicity and chemical composition. This symposium features the newest developments in FLIM and SRM combined with novel biological applications across cancer, neurodegeneration, and cellular and molecular biophysics.

 

Physical Sciences Symposia

P01 - Advanced Imaging and Spectroscopy for Nanoscale Materials Characterization

ORGANIZERS:
Lin Zhou, Ames Laboratory
David Cullen, Oak Ridge National Laboratory
Ping Lu, Sandia National Laboratories

Multimodal imaging and spectroscopy provide an unprecedented opportunity for materials characterization by using a combination of high-speed, high-sensitivity detectors and spectrometers. The chemistry and structure of crystals, interfaces, and defects down to the atomic-scale can now be directly determined under proper experimental conditions. Such capabilities offer a unique perspective to understand the structure-property relationships and pave the way towards material functionality manipulation from the atomic scale. This symposium is intended to facilitate the exchange of information on the latest developments, challenges, and outlooks in the application of advanced imaging and spectroscopy methods on resolving structures and chemistry in various materials systems, including metals, oxides, and semiconductors.

P02 - Many Detectors Make Lights Work: Advances in Microanalysis of Light Elements in Synthetic and Natural Materials

ORGANIZERS:
Anette von der Handt, University of Minnesota
Jed Mosenfelder, University of Minnesota
Owen Neill, University of Michigan
Jamie Weaver, National Institute of Standards and Technology

Measurement of light elements (hydrogen through fluorine, Z=1-9) presents unique challenges not encountered when measuring elements Z > 9, but is nonetheless critical for a variety of applications, across a range of disciplines. Various techniques are available (WDS, EDS, EELS, SIMS, FTIR, neutron activation, etc.), all with their own advantages and disadvantages. Sample preparation is often a critical component for its analytical success. This symposium will highlight advances in the measurement of light elements in the materials, energy, biological and natural sciences. Presentations showcasing new technologies for the detection of light elements, improvements to existing methods, and old and new methods to analyze light elements are all welcome.

P03 - Exploring Beam-sample Interactions for Uncovering the Atomic or Dynamic Nature of Matter

ORGANIZERS:
Joe Patterson, University of California, Irvine
Stig Helveg, Technical University of Denmark
Jennifer Cookman, University of Limerick

In high resolution electron microscopy objects are actively altered by the intense electron beam irradiation. For the accurate and precise measurement of a structure or process, it is essential that the role of the electron beam is interpretable or negligible. This symposium welcomes contributions from those that exploit the electron beam to deliberately initiate or modify a structure or process or obtain an understanding of a structure or process by imaging below a damage threshold. Contributions are especially encouraged for new theories, experimental set-ups, data collection and image processing.

P04 - Emerging Low-Dimensional Nanomaterials and Their Heterostructures

ORGANIZERS:
Moon Kim, University of Texas at Dallas
Zonghoon Lee, Ulsan National Institute of Science and Technology (UNIST) / Institute for Basic Science (IBS)

New materials and devices can lead to disruptive advances in nano-electronics, energy, and environmental sectors. For example, carbon-based materials and devices have made significant progress, and yet still more need to be accomplished. The recent advent of 2D TMDs and MXenes is stimulating new applications in many new areas. This symposium focuses on analytical transmission electron microscopy techniques, aberration-correction, spectroscopy, and in-situ methods to characterize these emerging low dimensional materials of interest. Presentations are sought from the areas of various forms of carbon, other novel nanomaterials, and their heterostructures.

P05 - Evaluation of Materials for Nuclear Applications

ORGANIZERS:
Mukesh Bachhav, Idaho National Laboratory
Assel Aitkaliyeva, University of Florida
Jing Wang, Pacific Northwest National Laboratory

The response of fuels and materials to radiation is critical to the performance of advanced nuclear systems. Key to understanding material performance in a nuclear environment is the microstructural characterization of materials irradiated using test reactors and ion beam facilities. This symposium will focus on recent results produced from irradiation programs around the world and advances made in microscopy, with an emphasis on application of latest-generation methods of microscopy and microanalysis such as atom probe tomography, transmission electron microscopy, aberration-corrected microscopy, transmission Kikuchi diffraction, plasma FIB, advanced data analytics, scanned probe microscopy and nano-mechanics, in situ microscopy, and other new methods.

P06 - Defects in Materials: How We See and Understand Them

ORGANIZERS:
Jinwoo Hwang, The Ohio State University
Tyler Grassman, The Ohio State University
Honggyu Kim, University of Florida

Controlling defects in next-generation materials is crucial as they critically affect the materials' important properties. Investigating atomic to nanoscale defects, however, poses significant challenges due to the small size and often elusive nature of those defects. The role of modern electron microscopy in determining atomic to nanoscale defects has become more important than ever as it provides both spatial and time resolution unmatched by others. This symposium will focus on recent studies investigating static and dynamic nature of atomic to nanometer scale defects that directly govern the emergent properties of a broad range of new generation electronic, functional, and structural materials.

P07 - Quantum Materials Probed by High Spatial and Energy Resolution in Scanning/Transmission Electron Microscopy

ORGANIZERS:
Nasim Alem Alem, Penn State University
Mary Scott, University of California Berkeley

This symposium will focus on the recent advancements in probing nanostructures and quantum materials using high energy and/or spatial resolution in Scanning/Transmission electron microscopy. By bringing together imaging and spectroscopy at high spatial and energy resolutions, this symposium aims to directly connect the role of structure to local properties and further uncover their underlying physics and chemistry. This symposium includes recent advancements in high resolution imaging of the defects and interfaces in nanostructures and their relaxation effects, probing their local chemical/electronic structure, understanding the phonon and plasmon resonances at the defects, interfaces, and surfaces in nanostructures, and studies of topological, skyrmionic, superconducting and other quantum materials.

P08 - Advanced Characterization of Components Fabricated by Additive Manufacturing

ORGANIZERS:
Isabella van Rooyen, Idaho National laboratory
Subhashish Meher, Idaho National Laboratory
Federico Sciammarella, MXD USA

Contributions are invited from researchers developing or leveraging advanced characterization methods for understanding of components fabricated by additive manufacturing (AM) techniques. The second edition of this symposium is intended to be an information exchange forum for cutting-edge microscopy and microanalysis techniques to assess the microstructural design aspects of existing materials and novel materials by various AM method types.

P09 - Nanoscale x-ray and Electron Microscopy Techniques and Applications in Material Science

ORGANIZERS:
Xianghui Xiao, Brookhaven National Laboratory
Hanfei Yan, Brookhaven National Laboratory
Huolin Xin, University of California, Irvine

A material's chemical and physical properties are closely related to its structural and compositional variations at atomic and nanometer scales, while at the device level, a system's performance depends on the interactions amongst its components. Therefore, a characterization tool suite that can cover multiple length scales is critically important to the material science community. The proposed symposium will cover both techniques and applications of two types of ubiquitous microscopy modalities, electron and x-ray microscopy. The emphasis focuses on utilizing the combined characterizations to reveal the correlations between the fundamental material properties and system-level properties.

P10 - Investigating Phase Transitions in Functional Materials and Devices by In Situ/Operando TEM

ORGANIZERS:
Michele Conroy, University of Limerick
Trevor Almeida, University of Glasgow
Leopoldo Molina-Luna, TU Darmstadt
Judy Cha, Yale

The possibility to control phase transitions in functional materials and devices within the TEM provides fundamental insight into dynamic, localised processes that were previously inaccessible. The development of in-situ TEM capabilities (heating, biasing, cooling, magnetic fields, etc.) and their combination with advanced TEM techniques (phase-related, spectroscopy, 4D-STEM etc.) enables operando studies to characterize the physical properties of materials at the highest resolution while simultaneously measuring their functional performance. These innovative investigations provide a wealth of information that opens a plethora of opportunities to study functional materials and devices in a range of new applications. This proposed symposium invites in-situ (S)TEM experiments that utilise not only applied stimulus via in-situ TEM holders, but also controlled electron-beam-induced transitions. The main goal is to bring together experimental and theoretical TEM researchers that employ a range of in-situ/operando methods to understand the fundamental physics governing the nano- to atomic-scale phase transitions of functional materials and devices.

P11 - Fast and Ultrafast Dynamics Using Electron Microscopy

ORGANIZERS:
Ilke Arslan, Argonne National Laboratory, Center for Nanoscale Materials
David Flannigan, University of Minnesota, Dept. of Chemical Engineering and Materials Science
Pietro Musumeci, University of California, Los Angeles, Physics Dept.

This symposium will focus on advances in the study of fast and ultrafast physical, chemical, and materials dynamics (structural, electronic, and magnetic) with scanning and transmission electron microscopy instrumentation and methods. In addition to communicating technology developments and the new scientific advances resulting from ultrafast electron microscopy (UEM) experiments, a goal of this symposium is to stimulate discussions on future directions of fast and ultrafast EM and to foster the formation of new collaborations and exciting emerging research directions within the community.

P12 - Microscopy & Spectroscopy of Energy Conversion and Storage Materials

ORGANIZERS:
Lianfeng Zou, Pacific Northwest National Laboratory
Katherine Jungjohann, Sandia National Laboratories
pengfei yan, Beijing University of Technology, China
Michael Zachman, Oak Ridge National Laboratory

A rich variety of electron, X-ray, and neutron imaging, diffraction, spectroscopy, and tomography techniques have become powerful tools for enabling multimodal characterization of nanomaterials related to energy conversion and storage. This symposium focuses on the developments of advanced techniques and their applications in studying the physical and chemical properties, phase transitions, degradation mechanisms, and electronic and mass transport of energy-related materials. Ex situ (post mortem), in situ (exposed to external stimuli), and operando (under synthesis/working/processing conditions) characterizations of batteries, solar energy, nuclear energy, fuel cells, thermoelectrics, ferroelectrics, piezoelectrics, and catalysts are of interest for this symposium.

P13 - Advanced Application of Atom Probe Tomography: Specimen preparation, Instrumentation, and Data analysis

ORGANIZERS:
Daniel Perea, Pacific Northwestern National Labs, Richland, Washington, USA
James Douglas, Dept of Materials, University of Oxford, Oxford, UK
Daniel Haley, Dept of Materials, University of Oxford, Oxford, UK

Atom probe tomography (APT) continues to be an invaluable analytical technique to provide near-atomic scale 3D composition and structure mapping in metallic and semiconductor systems. However, new advancements in specimen preparation, experimental protocols and instrumentation, and data analysis are allowing a broader scope of application to previously unexaminable material systems. Complementary analytical microscopy and spectroscopy techniques and emerging tools for advanced specimen preparation, such as plasma-FIB, provide new avenues for sample processing, but also pose new challenges. Additionally, traditional methods for analyzing APT data are often insufficient to resolve ambiguities (e.g. convolution of mass peaks) or extract desired information from datasets to allow the best utilization of the acquired data.

This symposium will focus broadly on the latest developments related to specimen preparation, hardware and instrumentation, as well as computation and data analysis that enable advance characterization, material design, and discovery within novel and emerging material system.

MSA MAS